Mostrar mensagens com a etiqueta experimentação embrionária. Mostrar todas as mensagens
Mostrar mensagens com a etiqueta experimentação embrionária. Mostrar todas as mensagens

quarta-feira, 4 de dezembro de 2013

A Programme for the future with one foot in the past - There were strong reasons for the EU not to miss the opportunity to take a step forward with regard to funding stem cell research - by José Ramos-Ascensão

In europeinfos
 
Seven years ago, in a Press release of 22.12.2006 relating to the final adoption of the 7th Research Framework Programme (FP7), the General Secretary of COMECE stated that “given that the financial means available for research are limited, EU funding must – in order to spend the available means in the most appropriate manner – concentrate on joint priorities.” This statement was produced in view of the possibility, foreseen under the FP7, of funding research in human embryonic stem cells (hESC), a research that entails the destruction of human embryos. If this was plainly valid in 2006, it is simply incomprehensible that the new programme, Horizon 2020, that has just been adopted by the European Parliament (EP), sticks with that wrong, ethically reproachable approach to research.

A key Programme with a major ethical problem

Horizon 2020 is an EU programme to run from 2014 to 2020 and was proposed in a legislative package of proposals presented by the European Commission on 20 November 2011. As a major instrument for promoting growth through research and innovation in the European Union Horizon 2020 is to be welcomed.

After almost two years and 1824 amendments tabled in the ITRE (Industry, Research and Energy) Committee of the European Parliament, the procedure has finally came to an end. Unfortunately, as regards the ethical framework of the Programme, some shortcomings have to be mentioned; for example, no reference is made to key principles applicable in the field: protection of human dignity and the principle of primacy of the human being – putting the interests and welfare of the human being before that of society or science.

Nevertheless, the major ethical problem of Horizon 2020 is still the possibility of funding research on hESC. On 21 November last, by voting against six amendments which reproduced the Opinion adopted on 18 November 2012 by the JURI (Legal Affairs) Committee, the EP Plenary upheld the common text allowing for such funding as already agreed with the Council in the context of the trilogue negotiations. It is worth saying that JURI is the EP Committee actually competent to analyse the compliance of European Union acts with primary law and for the interpretation of European law and the analysis of ethical questions related to new technologies.

A position grounded on solid reasons

The Secretariat of COMECE has voiced its position against funding such research on many occasions ever since the proposals were published (cf. Press release of 13.09.2012 and Press release of 7.12.2011). In October 2012 the Secretariat welcomed the granting of the Nobel Prize for Medicine for research on alternatives to embryonic stem cells research (cf. Press release of 8.10.2012).  Horizon 2020 as now adopted does not even prioritize funding research in alternative, much more promising research (can we still say that hESC are promising?) on non-ethically problematic sources of stem cells (see Europeinfos no. 140, of July-August 2011), and this is a matter for regret. On the other hand, the text of Horizon 2020 as adopted has not duly taken into consideration the ruling in the case of Greenpeace v. Brüstle, whereby the European Court of Justice reaffirmed the legal protection of the human embryo, defined as “any human ovum after fertilisation », and the non-patentability of inventions that make use hESC (see Europeinfos no. 139, of June 2011, and Europeinfos no. 144, of December 2011).

Inconsistency and perplexity

The EP Plenary also adopted an amendment referring to a statement of the European Commission on the ethical framework of Horizon 2020. This statement is very much the same as the one adopted by the Commission in 2006 with regard to FP7, so the status quo as concerns funding research on hESC is basically maintained. By paragraph 12 of the statement now adopted, the Commission commits itself to “continue with the current practice» which means that it will not  consider «projects which include research activities which destroy human embryos, including for the procurement of stem cells», making sure however that «the exclusion of funding of this step of research will not prevent Community funding of subsequent steps involving human embryonic stem cells». This is rather inconsistent from an ethical perspective, especially if we bear in mind that such funding of subsequent steps stimulates the procurement of hESC and, thus, escalates human embryo-destructive research. The Secretariat of COMECE has always upheld the exclusion of any research involving the use of hESC including in steps subsequent to their derivation.

Meanwhile, as the European citizens’ initiative One of Us (see Europeinfos no. 150, of June 2012) calls for the EU to stop funding such kinds of research, the reply is much awaited to a Question for written answer asking what measures will the Commission take to ensure that the adoption of Horizon 2020 will not pre-empt such an initiative, the biggest so far with about 1.9 million signatures.

By way of a conclusion to what has been said above, one can say that for ethical reasons, but also in the light of new scientific and legal developments and their impact on the economic rationale of research, it is surely to regret the missed opportunity to take this step forward in the field of EU research policy with regard to stem cells.

quarta-feira, 17 de abril de 2013

Engineering our way to a eugenic future - by Philippa Taylor

In MercatorNet

The UK fertility regulator has proposed a "minor" procedure with momentous consequences which is legal nowhere else in the world

You may consider the following headline from a leading US newspaper blog last week to be rather extreme: "The British Embryo Authority and the Chamber of Eugenics". But when it is followed a week later by a news report in a British newspaper saying: "Lord Robert Winston warning over child ‘eugenics’", should we then take more notice?

The spur to these news reports was the publication of the UK fertility regulator’s report on whether to recommend mitochondrial manipulation in the UK. I have written about the proposed "treatment" for mitochondrial disorders in previous blogs (see here and in a CMF submission). Briefly, mitochondria replacement techniques, it is claimed, could enable parents to avoid passing debilitating and sometimes fatal mitochondrial diseases on to their children by using a donor’s mitochondria to create a healthy embryo (although it is a relatively rare disorder and only one child in 6,500 is affected by a serious mitochondrial disease).

This would be a form of germline genetic engineering. A child born following mitochondria replacement would share their DNA with three people: the male "donor" of the sperm, the female donor of the nuclear DNA and the female donor of the small number of mitochondrial DNA. Hence the headlines about three-parent babies.

The UK fertility regulator, the Human Fertilisation and Embryology Authority (HFEA) has been requesting views over the past year on whether these techniques should be made available to couples at risk of having an affected child. The HFEA has just concluded that: "Our advice to Government, set out in this report, is that there is general support for permitting mitochondria replacement in the UK, so long as it is safe enough to offer in a treatment setting and is done so within a regulatory framework."

So why the negative headlines about eugenics when this research could save lives and the HFEA seems to think it is safe enough to use?

1. This technique will not save the life of any child born with mitochondrial disorders. Indeed, children will still be born with mitochondrial disorders because it is not always possible to determine which child (embryo) will be affected, how severely and at what age. This research is not about treatment of affected individuals but about trying to create unaffected individuals through genetic manipulation of the germline.

2. No other country in the world allows this technique, using germline manipulation, to take place. Over 60 countries specifically prohibit human germline engineering because of its profound social, ethical and unpredictable safety consequences for future generations. (Any mistakes and unknown consequences will transmit to subsequent offspring and become part of their genome). Scientists in countries that have not yet adopted public policies on human germline modification have nevertheless observed the prohibition.

3. Once genetic manipulation of a human life is permitted – as it almost certainly will be in the UK now – even if just for these rare mitochondrial disorders, it will be impossible to hold a line to prevent germline intervention (and engineering) being carried out for other diseases, for other reasons, and for less serious disorders. Where will we draw the line?

4. Which brings us to my fourth point, and back to the beginning of this blog, that once we start to modify human lives, and cannot realistically hold a firm line, then we face a eugenic future.

This new form of eugenics (the improvement of humans by deliberately choosing their inherited traits) uses a kinder, gentler language, clothed with words such as choice and freedom, to enable the same inherently offensive and discriminatory distinctions that used to be made between the so-called "fit" and "unfit". Today many people believe they have not just a "right" to a child but also a right to choose a particular kind of child.

Along with access to new genetic technologies, there seems to be a greater willingness on the part of scientists and prospective parents to take risks with future lives and a readiness to pick and choose other characteristics.

Yet genetically changing a human person – however little or much – turns that human into a designed product, modifiable at will, without consent. Hence Robert Winston’s concern:

"Genetic technologies could be exploited in the future to produce more intelligent, stronger and attractive offspring… current controls will not be able to keep pace with advances in reproductive technologies… a form of eugenics could lead to people wanting to modify their children to enhance 'desirable characteristics' such as intelligence and beauty."

He adds that: "I think that the HFEA is not capable of regulating either the commercial aspects of reproductive technologies or the risks that people who undergo these technologies really run."

These concerns have been repeated by others, such as: Stuart Newman, a Professor of Cell Biology: "This attempt to improve future people is not medicine but a new form of eugenics. In its willingness to risk producing damaged offspring by modifying embryos’ genomes, this 'correctionist' eugenics goes even beyond the “selectionist” version."

They have also been voiced by several high profile academics in the UK and US who warn in a letter with the headline: "Eugenics fear over gene modification" that: "we should not cross this ethical line, since it is likely to lead to a future of genetically modified 'designer' babies."

Because of these four concerns, and indeed others not mentioned here, of the 1,836 responses to the public consultation by the HFEA a majority of respondents, (including the CMF) disagreed with the introduction of mitochondria replacement techniques and a majority argued against changing the law. This article has more analysis of the public responses and the HFEA’s rather misleading conclusion in its recommendation to Government.

We have warned frequently at CMF about our concerns with a "new" eugenics (a quick search on the CMF blog page will throw up a number) but this new research does take us one significant step closer, and this time there are many other people ringing the warning bells.

Humans, at whatever stage of life or ability, should be respected and accepted as equals not selected and designed (or improved) to fit another’s whim or will.

Society’s eugenic mindset and increasing obsession with celebrity status, physical perfection and high intelligence all fuels the view that the lives of people with disabilities or genetic disorders are somehow less worth living.

I’m writing this at Easter time and although this is out of context, this verse from Luke struck me with some poignancy when read at our Good Friday service, as I had been thinking about this particular issue: "Turning to them Jesus said. ‘Daughters of Jerusalem, do not weep for me, but weep for yourselves and for your children." Sadly, this may be all we can now do for the children who will one day be born of three genetic parents.

quarta-feira, 10 de abril de 2013

The Return of Eugenics - by William M. Briggs

In CRISIS 

It’s beginning to look a lot like 1913, a decade before the peak of the Social Darwinism movement, a time when educated and concerned people joined the Race Betterment Foundation and looked to the settled science of eugenics to save civilization from the growing horde of the genetically inferior.


Events have since made the word eugenics distasteful, but not the notion. The idea of human perfection via managed procreation is back and stronger than ever, at least in the academy. Now instead of forcible sterilization, the call is for fetal genetic testing and selective abortion. Race is no longer the marker of unfitness; having incorrect thoughts or unwelcome moral attitudes and genetic unworthiness are.


Early eugenicists embraced contraception. In 1921 Margaret Sanger argued birth control was “not merely of eugenic value, but is practically identical in ideal, with the final aims of Eugenics.” Two such aims were “racial regeneration” and “to improve the quality of the generations of the future.” She said the “unbalance between the birth rate of the ‘unfit’ and the ‘fit’” was “the greatest present menace to civilization.” She thought “Birth Control propaganda is thus the entering wedge for the Eugenic educator.” If undesirables didn’t voluntarily stop making babies, steps would be taken. “Possibly drastic and Spartan methods may be forced upon society if it continues complacently to encourage the chance and chaotic breeding that has resulted from our stupidly cruel sentimentalism.”


Spartans preferred exposure for the betterment of mankind while eugenicists touted culling and sterilizing the unfit, the breeding technique used by farmers to improve their stock. What was “unfit”? That was often left undefined, though Sanger pegged low IQ. She often trumpeted statistics like those which showed that 39% of white “charity obstetrical patients” at one hospital and “70% of the negroes were found to have a mental age of 11 years or less.”


Real and imagined racial disparities were eagerly discussed. Conclusions were drawn. Progress was made. But then came Hitler, concentration camps, and the horrific practical experience of purging racial impurity. Eugenicists were shamed and clammed up. The field lay fallow for half a century, until the rise of abortion “rights” and the expansion of the universities in the late twentieth century. There arose a new crop of academics convinced that if only they were put in charge, and just the right people were aborted, the world would be a better place.


Consider David DeGrazia, tenured at George Washington University, who in the Journal of Medical Ethics recently advocated creating a master race via programmatic “moral bioenhancement.” Like many, DeGrazia gazed upon the earth and saw “an abundance of immoral behaviour.” He worried “traditional means of moral enhancement may prove inadequate to achieve needed improvements,” therefore more drastic measures are called for. Such as selection “of embryos that contain a gene coding for a greater disposition to altruism” or even implanting an “artificial chromosome that includes multiple genes coding for stronger predispositions to a variety of moral virtues.”


He disfavors letting emerge from the womb those whose DNA codes for “moral cynicism” (he cites tax cheats), those not wanting to contribute “one’s fair share,” those with “defective empathy,” those who suffer “a failure of insight or motivation,” including those not wanting to donate more than 1% of the USA’s GDP to foreign governments (yes, truly). Who decides on the list of desirable and therefore allowable traits? Well, people like DeGrazia, though he concedes “it might make sense to permit parents to adopt more debatable visions of morality—among reasonable alternatives.”


The buzzword among cognoscenti is “post-person,” defined in a much-cited 2009 Philosophy and Public Affairs paper by tenured Duke professor Allen Buchanan, as those “who would have a higher moral status than that possessed by normal human beings” (emphasis original). Buchanan admits crafting chromosomal übermenschen “might be profoundly troubling from the perspective of the unenhanced (the mere persons) who would no longer enjoy the highest moral status, as they did when there were only persons and nonpersons (‘lower animals’).” There’s ample precedent to create this new hierarchy: “the profoundly demented and infants, do not have some of the characteristics that moral philosophers typically attribute to persons and that are thought to ground the distinctive rights that persons have.” Daniel Wikler, tenured at Harvard, agreed in a 2009 article contributed to Human Enhancement figuring that once we create super-moral beings, it makes sense to restrict the legal rights of the not-so-super.


Nicholas Agar of the University of Wellington is one of only a small (and decreasing) number of faculty who have read Mary Shelly. In a special issue of this year’s Journal of Medical Ethics he dared speculate about possible bad and unforeseen consequences and was immediately taken to task by a brace of academics, like Ingmar Persson (University of Gothenburg), who has predictably chided Agar for being “biased” against post-persons.


As is plain, the leading new-eugenics organ is the Journal of Medical Ethics, edited by Julian Savulescu (tenured, St Cross College, Oxford), self-appointed champion of genetic tinkering. He is the public face of the movement, writing in Reader’s Digest that it is “our duty” to have “designer babies” (would their color go with our shoes?) and that “people have a moral obligation to select ethically better children.”


He claims, “We now know that most psychological characteristics are significantly determined by certain genes,” like, the “COMT gene” which selects for altruism (new-eugenicists really go for altruism). If you want your child “to be faithful and enjoy stable relationships” then abort him if he has “a variant of AVPR1.” Kill him, too, if he’s saddled with “a certain type of the MA0A gene” which is “linked to higher levels of violence in children who often suffer abuse or deprivation.”


Savulescu and the other new-eugenicists making these sorts of arguments delude themselves. “We” do not know that psychological characteristics are significantly determined by certain genes. And, as Yoav Benjamini and others have confirmed, the possibility of falsely associating a trait with a gene is high. If your baby is discovered to have “a version of the COMT gene” it does not mean that he will necessarily be altruistic. He may well grow up to be a cad. The implied claim that biology explains all or most behavior is false—do all identical twins act identically?


It is true that some genes are associated with some behaviors, but the association is statistical. Experiments with very limited numbers of (mostly white, educated, young, Western) volunteers show that more people who exhibit a specific behavior, or that fail to exhibit another, are more likely to have or lack certain genes than others in the experiments. Having a certain gene or genes thus does not mean a person will exhibit, or fail to exhibit, a behavior, especially a behavior as complex as altruism, which can only be measured crudely. Therefore it is absurd to say that by killing those who possess or lack a given gene will certainly promote desirable behaviors. Plus, nobody has any idea what would happen to the human population if certain genes are systematically removed (via abortion) or inserted (via injection). Perhaps the post-persons created in this program will be more altruistic, but they may also be more indolent or stupid as a consequence. To claim that this cannot be so is to argue wishfully, without evidence.


New-eugenicists aren’t claiming definitiveness, however. They know that gene-behavior connections are correlational and that behavior is difficult to unambiguously define. They know they’re using the “loaded-dice” argument such that aborting those with or without approved genes only increases the chances of desired behaviors, but doesn’t guarantee them. They know the correlations are weak, but they claim they’re good enough.


But just think. Here in the United States there are certain genes positively associated with crime, particularly violent crime. One group of people sporting a certain gene combination commit proportionally far more crime than others lacking these genes. This association is strong, vastly stronger than the correlation between altruism and the COMT gene, or any other gene-behavior connection; the statistical evidence is indisputable. Savulescu and his brother eugenicists’ logic is that those who display these genes should be aborted to create a better society. Who but an academic could get away with making arguments like this?


Legal abortion guarantees eugenics. Already, babies testing for Down’s syndrome are often aborted. Scientists have recently derived tests to discover over 3,500 genetic “faults.” It’s early days with the technology, so expect that number to rise, with definitions of “faults” increasingly provided by new-eugenicists. What’s forgotten in this rush for perfection is that no test is error free, and the error rate of the test depends on the “fault,” which means that a certain fraction of the pre-born who are killed will die healthy, wrongly suspected as having “faults.” But you can’t make an omelette, etc.


Eugenics via abortion for sex selection is legal in the United States, and even touted. The Manhattan-based Center For Human Reproduction tells pregnant women they may want to abort if they are concerned about diseases which “are inherited via the mother but only male offspring are affected (muscular dystrophy, hemophilia, etc.). In other cases, conditions are more severely expressed in one gender (Fragile X syndrome, autism in males, etc.) than the other.” They’re not suggesting your unborn baby boy is unhealthy, but they warn against having a boy because boys in general are less healthy. Curiously, the bias here is against males and not females as it is in the rest of the world. Congress gave itself a chance to ban sex selection, but in 2012 they voted down the Prenatal Nondiscrimination Act which would have made such abortions illegal.


New-eugenicists know that, despite their best and most earnest efforts, a few unauthorized babies will slip past the goalie. Sensitivity training can’t cure them all. Academic philosophers Alberto Giubilini and Francesca Minerva say kill ‘em while they’re still infants, before they have a chance to use their forbidden genes. The pair call their procedure “after-birth abortion.” The subtitle of their 2012 JME paper is “Why should the baby live?” Their argument? The “moral status of an infant is equivalent to that of a fetus in the sense that both lack those properties that justify the attribution of a right to life to an individual.”


For the small fraction of genetically inferior who make it out of the womb and past Giubilini’s and Minerva’s abattoir, there is always sterilization (as practiced by China, say) or drugs. For example, some claim propranolol douses racism. Sterilization is eugenics, but drugging somebody might seem not, or at least not per se. But administration of chemicals can interfere directly with the ability to procreate, or it might alter behaviors which are correlated with procreation, and that makes it eugenics.


Yet drugs, or rather “enhancement” of the already living, is not as optimal as eugenics argues Savulescu, particularly when it comes to eliminating lawlessness. In a 2006 Journal of Applied Philosophy paper he said “specific genetic markers” can be tied to “criminal tendency,” i.e. that criminality is heritable. That’s what he writes from the safety of his ivory tower. Hey, Julian, let’s me and you head to a pub in Melbourne and you can tell the blokes there what it would be like if a country was populated only by criminals with their heritable genes. Should make for an interesting discussion.

quarta-feira, 13 de junho de 2012

Fertilización in vitro con “tres padres” es muy peligrosa, alertan pro-vidas

LONDRES, 13 Jun. 12 / 05:10 am (ACI/EWTN Noticias).- La organización pro-vida británica Sociedad para la Protección de los Niños No Nacidos (SPUC por sus siglas en inglés) advirtió que un nuevo tratamiento de fertilidad con "tres padres", que pretende prevenir enfermedades genéticas, es muy peligroso y puede llevar al desarrollo de anormalidades en el embrión.

Este método de fertilización artificial se conoce como de "tres padres", porque el embrión tiene genes de una madre, un padre y una donante extra de sexo femenino, en un intento por remover y reemplazar ADN mitocondrial considerado "defectuoso".

En un comunicado emitido el 12 de junio, el encargado de comunicaciones de SPUC, Anthony Ozimic, señaló que "así como con la fecundación in vitro y la clonación, estas técnicas mitocondriales podrían llevar al desarrollo de anormalidades".

"Crear niños en fase embrionaria en el laboratorio es abusar de ellos, sometiéndolos a procesos innaturales. Estas técnicas son tanto destructivas como peligrosas, y por tanto no son éticas".

Ozimic denunció que "la gran mayoría de niños en fase embrionaria creados en el laboratorio son asesinados porque no alcanzan los requerimientos del ‘control de calidad’ establecidos por los científicos involucrados en esos experimentos cada vez más macabros".

"Los científicos deberían abandonar el campo espurio de la destructiva experimentación con embriones y, en su lugar, promover la alternativa ética de la investigación de células madres adultas, que ya está proveyendo curas y tratamientos para un creciente número de enfermedades".
En su comunicado, el grupo pro-vida, que ha sido consultado sobre temas de bioética por comités del parlamento británico, también criticó el informe remitido por el Nuffield Council on Bioethics, que consideró como una opción de tratamiento ética la fecundación de "tres padres".